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KMID : 0380620080400060691
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Korean Journal of Food Science and Technology
2008 Volume.40 No. 6 p.691 ~ p.696
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Glycoprotein Isolated from Morus indica Linne Enhances Detoxicant Enzyme Activities and Lowers Plasma Cholesterol in ICR Mice
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Shim Jae-Uoong
Lim Kye-Taek
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Abstract
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The objective of this study was to evaluate the effects of glycoprotein isolated from Morus indica L. (MIL)on plasma cholesterol levels and on the activities of hepatic detoxicant enzymes in ICR mice. MIL glycoprotein evidencedgood scavenging activities against lipid peroxyl radicals. When the mice were treated with Triton WR-1339, the levels oftotal cholesterol (TC) and low-density lipoprotein (LDL)-cholesterol in plasma increased significantly by 53.9 and 47.5mg/dL, respectively, as compared to the controls. However, when pretreated with MIL glycoprotein (100μg/mL), ICR miceshowed marked reductions to 55.4 and 47.0mg/dL, as compared to Triton WR-1339 treatment alone. Interestingly, highdensity lipoprotein cholesterol levels were unchanged. These results indicate that the MIL glycoprotein is capable ofscavenging lipidperoxyl radicals, lowering plasma lipid levels, and increasing the activities of detoxicant enzymes in themouse liver.
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KEYWORD
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glycoprotein, Morus indica L., cholesterol, detoxicant enzymes, antioxidant
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